2-Amino-3-cyano-4-hydroxyquinolines

摘要

The reaction of isatoic anhydrides with malononitrile in a reaction- inert solvent in the presence of a base to produce 2-amino-3- cyano-4- hydroxyquinolines and 2-amino-&agr;,&agr;-dicyanoacetophenones which are then hydrolyzed and decarboxylated under acid or base conditions to produce 2-amino-4-hydroxyquinolines, useful as intermediates for preparation of 1-oxo-1H-6-alkoxypyrimido 1,2- a!quinoline-2-carboxylic acids and esters of value as antiallergy agents.