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Amino-substituted nitrobenzophenone derivatives with alkyl, phenyl, phenyl alkyl or cycloalkyl amino-substituting groups

机译:具有烷基,苯基,苯基烷基或环烷基氨基取代基的氨基取代的硝基二苯甲酮衍生物

摘要

Compounds of the formula (I), ##STR1## wherein R.sub.1 and R. sub.2 each is saturated or unsaturated, straight-chained or branched alkyl phenyl, alkylphenyl or saturated or unsaturated cycloalkyl;P Pbut when R.sub.1 is methyl, R.sub.2 is a group other than methyl, are prepared by reacting a compound of the formula (II), ##STR2## wherein X is halogen, with a secondary amine of the formula (III), ##EQU1## The new compounds of the formula (I), as well as their pharmaceutically acceptable acid addition salts are active primarily in the induction of liver microsomal enzyme, but also possess antipyretic activity.
机译:式(I)的化合物,其中R 1和R 2各自为饱和或不饱和的,直链或支链的烷基苯基,烷基苯基或饱和或不饱和的环烷基; P>但是当R 1是甲基时,R 2是除甲基以外的基团,是通过将式(II)的化合物(其中X是卤素)与仲式(III)的胺,式(I)的新化合物及其药学上可接受的酸加成盐主要在诱导肝微粒体酶方面具有活性,但也具有解热活性。

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