首页> 外国专利> MANUFACTURE OF 66AMINOO66DESOXYY2*33OO ISOPROPYLIDENEEALPHAALL SORBOFURANOSE DERIVATIVE AND NOVEL INTERMEDIATE PRODUCT

MANUFACTURE OF 66AMINOO66DESOXYY2*33OO ISOPROPYLIDENEEALPHAALL SORBOFURANOSE DERIVATIVE AND NOVEL INTERMEDIATE PRODUCT

机译:66 AMINOO66DESOXYY2*33OO异丙烯撑山梨醇呋喃酯衍生物和新型中间产物的制造

摘要

The invention relates, inter alia, to a process for the provision of 6-amino-6-desoxy-2,3-O-isopropylidene- alpha -L-sorbofuranose derivatives which comprises treating a 2,3-O-isopropylidene-6-sulphonated- alpha -L-sorbofuranase with an amine in an aqueous medium in an autoclave, followed by reaction of the reactions product in a basic medium to provide the free amine of Formula I as described hereinafter. The invention also includes the products obtained by the reaction and the invention further includes the process for providing the compounds of Formula VII as described hereinafter by treatment of a compound of Formula I as described hereinafter with an acid, followed by hydrogenation. The products of the invention are useful as medicaments or intermediates for medicaments.
机译:本发明尤其涉及提供6-氨基-6-脱氧-2,3-O-异亚丙基-α-L-呋喃呋喃糖衍生物的方法,该方法包括处理2,3-O-异亚丙基-6-。在高压釜中的水性介质中,将胺与磺化的α-L-L-山梨聚糖酶进行胺化,然后使反应产物在碱性介质中反应,以提供下文所述的式I的游离胺。本发明还包括通过该反应获得的产物,并且本发明进一步包括通过用酸处理下文所述的式I化合物,然后氢化来提供下文所述的式VII化合物的方法。本发明的产品可用作药物或药物的中间体。

著录项

  • 公开/公告号JPS5645498A

    专利类型

  • 公开/公告日1981-04-25

    原文格式PDF

  • 申请/专利权人 BAYER AG;

    申请/专利号JP19800122460

  • 申请日1980-09-05

  • 分类号C07H9/04;C07H15/12;

  • 国家 JP

  • 入库时间 2022-08-22 16:32:33

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