method for preparing a medicine with adrenolytische properties that a 8 beta - aminomethyl - 6 - methyl 10 alpha ergolinederivaat contains, and the resulting product formed.and method for the preparation of appropriate 8 beta - aminomethyl - 6 - methyl 10 alpha ergolinederivaten.

摘要

Title derivs. of formula (I) (where R is H or CH3 R1 and R2 are H, 1-3C alkyl or phenyl, and R3 is H, halogen, CH3, C2H5, OCH3, OC2H5 phenyl, NO2, (acyl)amino CN or carboxamido) which are long-acting adrenolytics with low toxicity, are prepd. by reacting dihydrolysergamine or 1-methyl-dihydrolysergamine with a cpd. which is capable of converting the amino gp. into a guanidino gp. reacting the resulting 6-methyl-or 1,6-dimethyl-8 beta-guanidinomethyl-10 alpha-ergoline with a beta-dicarbonyl cpd. of the formula R1-CO-CHR3-CO-R2 at 10-150 degrees C for 1 hr. to 6 days; and isolating and pyrifying the resulting (I).