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ANALOGIFREMGANGSMAADE PRODUCING quaternary DERIVATIVES OF SANDWICIN
ANALOGIFREMGANGSMAADE PRODUCING quaternary DERIVATIVES OF SANDWICIN
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机译:拟金刚霉素产生Sandwicin的四元衍生物
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摘要
Novel sandwicinium salts of the formula I IMAGE in which R represents an alkyl group having up to 5 carbon atoms, are obtained by reacting sandwicin with an appropriate alkyl halide. In order to convert the halide into another salt of the formula I', in which X denotes the anion of an organic or inorganic acid, the halide is converted with alkali into the corresponding, open-ring, aldehyde base, which, together with an appropriate acid, yields the desired salt. The novel salts exhibit adrenolytic and cardiac-rhythm-promoting activity. IMAGE
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