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PROCES FOR PREPARING WATER SOLUTION OF THE COMPLEX OF 3-CHLORO-4-/P-CHLOROPHENOXY/-3,5-DIIODOSALICYLOANILIDE WITH POLYVINYL PYRROLIDONE
PROCES FOR PREPARING WATER SOLUTION OF THE COMPLEX OF 3-CHLORO-4-/P-CHLOROPHENOXY/-3,5-DIIODOSALICYLOANILIDE WITH POLYVINYL PYRROLIDONE
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机译:制备3-氯-4- /对氯苯氧基/ -3,5-二碘二水杨酰苯胺与聚乙烯吡咯烷酮配合物的水溶液
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摘要
A soluble complex of an insoluble drug, exemplified by Rafoxanide, is formed with polyvinylpyrrolidone and water. The complex is formed by combining the insoluble drug and polyvinylpyrrolidone in a suitable water-miscible organic solvent, preferably acetone or glycerolformal, and water. The complex is formed in situ. The solvent may be removed, if desired, and the complex remains in aqueous solution. The aqueous solution is then suitable for injection and may be used to treat fasciola or liver fluke infections.
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