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PROCESS FOR PREPARING SUSPENSION OF MICROENCAPSULATED BACAMPICILLIN ACID ADDITION SALT ORAL ESPECIALLY PEDIATRIC ADMINISTRATION
PROCESS FOR PREPARING SUSPENSION OF MICROENCAPSULATED BACAMPICILLIN ACID ADDITION SALT ORAL ESPECIALLY PEDIATRIC ADMINISTRATION
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机译:制备微胶囊化的苄青霉素酸加成盐,口服盐,特别是儿科给药的悬浮液
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摘要
A novel formulation of bacampicillin for oral administration is disclosed. Microcapsules comprising an acid addition salt of bacampicillin coated with a mixture of ethyl cellulose:water-soluble or water-permeable filler material are suspended in a buffered vehicle having a pH of at least 6.9. The novel suspension is characterized by palatable taste, surprisingly good stability and enhanced bioavailability after oral administration. The novel suspension is well suited for multiple dose oral administration. The preferred filler material is hydroxypropyl cellulose.
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