anvendning of optically active aluminiumhudridforeningar at hydreringsreaktioner for framstellning of optically active alcohols, amines and fosfiner

摘要

1460781 Reduction SNAMPROGETTI SpA 9 April 1974 [13 April 1973] 15781/74 Headings C2C and C2P The invention comprises a process for converting by hydrogen transfer a prochiral or racemic starting material to an optically active product, which process comprises reacting the starting material with an alane selected from (a) optically active aminoalanes having the two following general formulae and and (b) optically active polyiminoalanes having in their molecule a group having the general formula wherein X is a hydrogen, chlorine or bromine atom or a group of the formula -NRSP3/SP 2 or -ORSP3/SP, n is an integer having a value greater than 4, each of RSP1/SP, RSP2/SP and RSP3/SP, which can be the same or different, is an alkyl, aryl, alkaryl, aralkyl or cycloalkyl radical, or RSP1/SP and RSP2/SP together represent a divalent alkylene radical and with the nitrogen atom to which they are attached form a hetero ring; with the proviso that in the alane at least one radical attached to the nitrogen atom(s) contains at least one asymmetric centre, and with the proviso that in the polyiminoalane there is for each aluminium atom, at least one direct Al-N bond and in the polyiminoalane there is at least one Al-H bond. Examples describe the preparation of - methyl benzyl alcohol; but-2-yl-n-butylamine; 3 - methyl - 1 - phenyl - 1 - phosphacyclopent- 3-ene and 1,2-dimethyl-n-butylamine.