process for the preparation of a tiolcarbamato

摘要

Thiolcarbamates are prepared by reacting a secondary amine having the formula R1 ANGLE NH R2 wherein R1 and R2 are the same or different and each represent hydrogen, lower alkyl, alkoxy, alkenyl, alkoxyalkyl, cycloalkyl, hydroxyalkyl, benzyl or phenyl or R1 and R2 combined is a nitrogen containing heterocyclic ring with carbonylsulfide to form an intermediate of an amine salt of a thiolcarbamic acid having the formula R1O- R1+ PARALLEL ANGLE N-C-S NH2 ANGLE , R2 R2 wherein R1 and R2 are defined as above, in an organic solvent having the formula WHEREIN N IS 0, 1 OR 2 AND R' is hydrogen, halogen or a lower alkyl group which solvent is sparingly soluble or insoluble in water and which dissolves the amine salt of the thiolcarbonic acid, and then reacting the intermediate with an alkyl halide having the formula X - CH2 - R3 wherein X represents halogen, and R3 represents hydrogen, lower alkyl or naphthyl or phenyl which can be substituted with halogen, alkyl, alkoxy, alkylthio, cyano or nitro, to yield a thiolcarbamate having the formula R1O PARALLEL ANGLE N-C-S-CH2-R3. R2