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A process for preparing a penicillanic acid derivative of a substituted-6b
A process for preparing a penicillanic acid derivative of a substituted-6b
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机译:一种制备取代的6b青霉酸衍生物的方法
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摘要
6-Alpha and 6-beta-substituted penicillanic acid derivatives of the formula: IMAGE (I) wherein R is H or a conventional penicillin carboxy protecting group or an ester forming residue readily hydrolyzable in vivo and R1 is a perhaloalkyl group of from 1 to 4 carbon atoms wherein the halogen atoms are fluoro or chloro, undergo SN2 nucleophilic displacement with halide or azide ions with inversion of configuration at C-6 to yield the corresponding 6-beta or 6-alpha-halo- or azido-substituted product.
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