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Ergotamine preparation procedure of ergotoxine alkaloids and group
Ergotamine preparation procedure of ergotoxine alkaloids and group
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机译:麦角碱生物碱的麦角胺制备工艺及组
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摘要
1. A process for the preparation of ergotamine and alkaloids of the ergotoxine group, characterized in that the following operations are carried out in succession : a) preparation of sclerotes by grinding ergot of rye (Claviceps purpurea), previously impregnated with water or with an aqueous alkaline solution, by crushing to a grain size of less than 0.5 mm ; b) extraction in an acid medium of all the alkaloids using ethyl acetate, followed by isolation of all the alkaloids by precipitation using C6 or C7 saturated hydrocarbons ; c) purification of the alkaloids obtained in b) by solubilization in ethyl acetate and extraction using an aqueous acid solution, then precipitation of the alkaloids ; d) chromatographic separation of ergotamine from the other alkaloids on acid alumina and elution using methylethylketone containing 1 % of water.
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