首页>
外国专利>
A process for the preparation of bis-indole-alkaloids and acid addition salts thereof and new bis-indole-alkaloids, pharmaceutical compositions containing them and their use as antitumour agents.
A process for the preparation of bis-indole-alkaloids and acid addition salts thereof and new bis-indole-alkaloids, pharmaceutical compositions containing them and their use as antitumour agents.
A process for the preparation of diindolealkaloids, especially new compounds corresponding to vinblastine or leurosine, in which the N-methyl group is replaced by an N-CH2-OC2H5 group having antitumor properties. The starting compounds are subjected to oxidation by chromic acid or an alkali metal dichromate at temperatures from -90 DEG C. to -30 DEG C. but preferably below about -45 DEG C. when the new compounds are to be produced, ethanol being present in this case.
展开▼