PROCESS FOR THE PRODUCTION OF NEW IMIDAZOLE COMPOUNDS, AND CONVERSION OF SAID COMPOUNDS INTO (R)-3-(2-DEOXY- .beta.-D-ERYTHRO-PENTOFURANOSYL)-3,6,7,8- TETRAHYDROIMIDAZOL ¬4,5-D ¬1,3-DIAZEPIN-8- OL

摘要

Abstract of the Disclosure2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone, 6,7-dihytroimidazo[4,5-d][1,3]diazepin-8(3H)-one and acid-additionsalts thereof are disclosed. 2-Amino-1-(5-amino-1H-imidazol-4-yl)ethanone and its acid-addition salts are prepared bycatalytically reducing an acid-addition salt of 2-amino-1-[5-amino-1-(protected)-1H-imidazol-4-yl]ethanone. 6,7-Dihydro-imidazo[4,5-d][1,3]diazepin-8(3H)-one and its acid-additionsalts are prepared by reacting an acid-addition salt of 2-amino-1-(5-amino-1H-imidazol-4-yl)ethanone with a compoundable to contribute a formyl group. The later product maysubsequently be converted into (R)-3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol. Furanose derivatives of 6,7-dihydroimidazo[4,5-d][1,3]-diazepine are also disclosed and their methods of preparationLastly, a method for resolvlng an isomer mixture of 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo-[4,5-d][1,3]diazepin-8-ol compounds is related.-1-