OLIGO SACCHARIDIC FRACTIONS AND OLIGO SACCHARIDES HAVING BIOLOGICAL PROPERTIES,PREPARATION PROCESS THEREOF AND APPLICATIONS THEREOF AS MEDICAMENTS

摘要

Oligo saccharides obtained from heparin comprising heparinic constituents having a molecular weight comprised between 2000 and 50000. These oligo saccharides have a high affinity for AT (III) and a high YIN-WESSLER titre. The ratio of the YIN-WESSLER"s titre thereof to the USP titre thereof is at least 30. They are comprised of saccharidic chaines containing not more than eight saccharidic patterns. They have a characteristic signal in the region C-2 of the residue N-sulfate-glucosamin. They exhibit an antithrombotic activity and therefore are appropriate to be used as antithrombotic medicaments.