Furyl intermediates of cardenolides, their synthesis and production of cardenolides and their isomers therefrom

摘要

The invention relates to furyl intermediates useful in the preparation of synthetic cardenolides and their isomers, to the preparation thereof, and to the conversion of such intermediates into cardenolides. The process provides for the reaction of an unsaturated steroidal 17-ketone with an alkali or alkaline earth metal p-furyl compound to produce an allylic alcohol which is subjected to acetylation and allylic rearrangement. The resulting material is then hydrogenated to produce the furyl intermediate. Cardenolides are formed therefrom by oxidation of the furyl intermediates.