process for the production of 2 - (6 - methoxy - 2 - naphthyl) - propionic acid and di - (6 methoxy 2 naphthyl) zinc and 6 - methoxy - 2 - naphthylzinkhalogenid

摘要

1321347 Methoxynaphthyl zinc compounds and process for preparing methoxynaphthyl propionic acid therefrom SYNTEX CORP 29 Nov 1971 [4 Dec 1970] 55378/71 Headings C2C and C2J 2-(6-Methoxy-2-naphthyl) propionic acid is prepared by reacting I di-(6-methoxy-2- naphthyl)zinc or II a 6-methoxy-2-naphthyl zinc halide with a lower alkyl 2-halopropionate and hydrolysing the lower alkyl 2-(6-methoxy-2- naphthyl) propionate formed. The product may be optically resolved if desired. The halogen in the above reactants is chlorine, bromine or iodine. Compounds I and II are novel and may be prepared by reacting a 2-halo-6-methoxynaphthalane with Mg and reacting the Grignard reagent formed with an appropriate zinc halide.