(choleretisch esters or effective) salts of dehydrocholic acid, methods for their production and arzneipräparate containing these compounds

摘要

Choleretically active esters and salts of bile acids having the formula I II A-COO-Alk-NR1R2. HOOC-B +TS or A-COOH. R2R1N-Alk-OOC-B in which A-COO- is the rest of a bile acid; B-COO- is the rest of an acid which cooperates choleretically with a bile acid; Alk is an ethylene, propylene or isopropylene group, and R1 and R2, which are identical or different, represent a hydrogen atom or a lower alkyl group or together with the nitrogen atom form a heterocyclic ring which can contain another nitrogen or oxygen atom and which can be substituted with alkyl groups. Among the bile acids which are particularly useful are cholic acid, deoxycholic acid, chenodeoxycholic acid, dehydrocholic acid and lithocholic acid. The acid B can e.g., be one of the following acids: 1,2-dithiolan-3-valeric acid or a cinnamic acid such as e.g. 3-methoxy-4-hydroxy-cinnamic acid; or further orotic acid; a sulfur containing amino acid, such as cystein or methionin; or arginin.