Scleroprotein e.g. collagen, keratin or elastin transplants prodn. - involving treatment with glycerol or polyethylene glycol to improve biological stability

摘要

In a new procedure for the prodn. of scleroprotein transplants with improved biological stability from raw human or animal scleroprotein by treating with water, treating with hydrogen peroxide, defatting, washing and sterilising, the scleroprotein is treated with glycerol or polyethylene glycol after washing but before drying. The glycerol or polyethylene glycol treatment gives improved resistance to biological degradation. The transplants are soft, and do not require rehydration before use. The prod. is transparent so that e.g. in brain operations the biological fluids and brain can be viewed through the transplantate. The glycerol or polyethylene glycol (pref. molecular weight 400-2000) is pref. used in the form of an aqueous 5-50% solution. When the scleroprotein is human dura, it is particularly advantageous to use a 20-40% (esp. 30%) soln. of glycerol in water.