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Any cytostatic action acting pharmaceutical preparations, new ursa all derivatives and process for their preparation

机译:任何具有抗细胞生长作用的药物制剂,新熊草苷的所有衍生物及其制备方法

摘要

N-substituted-diglycidyl-isocyanurates having the formula: IMAGE wherein R represents a hydrocarbon-containing radical selected from the group consisting of alkyl, aryl, aralkyl, alkaryl and cycloalkyl, optionally containing: (a) heterocycles except epoxides, and unsaturation, and (b) substituents selected from the group consisting of halogen, hydroxyl, amino, N-substituted amino, mercapto, alkylmercapto, arylmercapto, alkylsulfoxy, arylsulfoxy, alkoxy, aryloxy and acyloxy, and R1 represents a member selected from the group consisting of hydrogen and alkyl having from 1 to 4 carbon atoms, as well as the method for preparing said N-substituted-diglycidyl-isocyanurates, therapeutic compositions with cytostatic action comprising said N-substituted-diglycidyl-isocyanurates, and a method of treatment of malignant neoplasias in warm-blooded animals by administering a therapeutically effective amount of said N-substituted-diglycidyl-isocyanurate.
机译:具有下式的N-取代的二缩水甘油基-异氰脲酸酯:其中R表示选自烷基,芳基,芳烷基,烷芳基和环烷基的含烃基,其任选地包含:(a)除环氧化物以外的杂环和不饱和基团(b)选自卤素,羟基,氨基,N-取代的氨基,巯基,烷基巯基,芳基巯基,烷基亚砜基,芳基亚砜基,烷氧基,芳基氧基和酰氧基的取代基,R1表示选自下组的成员:氢和具有1-4个碳原子的烷基,以及制备所述N-取代的二缩水甘油基-异氰脲酸酯的方法,具有所述细胞抑制作用的治疗组合物,所述的N-取代的二缩水甘油基-异氰脲酸酯,以及治疗恶性肿瘤的方法通过给予治疗有效量的所述N-取代的二缩水甘油基-异氰脲酸酯来治疗温血动物。

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