New amines and their application to the treatment of cardiovascular disease

摘要

For the preparation of novel hydroxyamines of the formula (I) IMAGE with the radicals as in Patent Claim 1, and of therapeutically acceptable acid addition salts of these compounds, a starting compound of the formula (II) IMAGE is used. This is reacted with an amine of the formula (III) IMAGE The resulting isomeric mixtures are separated into the pure isomers and the resulting racemates into the optical antipodes. The resulting free bases can be converted into their salts and the resulting salts converted into the corresponding free bases. Preferred compounds prepared are: 1) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-allylphenoxy)propan-2-ol, 2) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(2-methoxyethyl)phenoxy-propan-2 -ol, 3) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-allyl-phenoxy)propan -2-ol, 4) 1-[1-methyl-2-(2-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 5) 1-[1-methyl-2-(4-methylphenoxy)ethylamino]-3-(2-allylphenoxy)-propan-2 -ol, 6) 1-[1-methyl-2-(4-carbamylphenoxy)ethylamino]-3-(2-methylisonitrosometh ylphenoxy)propan-2-ol, 7) 1-[2-(4-carbamylphenoxy)ethylamino]-3-(3-allylphenoxy)-propan-2-ol. The compounds have a blocking effect on beta -receptors and can be employed for the treatment of cardiovascular disorders.