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New derivatives of -pyrido (4,3 - b) carbazoles (ellipticine compounds), substituted in position 1 by a chain polyamino, their preparation and their application as medicinal products
New derivatives of -pyrido (4,3 - b) carbazoles (ellipticine compounds), substituted in position 1 by a chain polyamino, their preparation and their application as medicinal products
The novel derivatives correspond to the general formula: IMAGE (I) in which R1 is a Y-(CH2)n -NR4R5 group, where Y represents a single bond or the group IMAGE R4 and R5, identical or different, are hydrogen or an alkyl radical, preferably a lower alkyl, or again form together a ring which can include heteroatoms, in particular nitrogen atoms. n is a number ranging from 1 to 10, notably from 2 to 7, R2 is a hydrogen atom, a lower alkyl group or an aralkyl group in which the alkyl substituent is a lower alkyl group, and R3 is a hydrogen atom or a CH3 group useful for the treatment of leukemias.
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机译:新的衍生物对应于通式:(I),其中R1是Y-(CH2)n -NR4R5基团,其中Y表示单键或基团 R4和R5,相同或不同, R 1是氢或烷基,优选是低级烷基,或再次一起形成可包含杂原子,特别是氮原子的环。 n为1至10,尤其是2至7的数字,R 2为氢原子,低级烷基或芳烷基,其中烷基取代基为低级烷基,且R 3为氢原子或CH 3该组可用于治疗白血病。
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