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Pharmaceutical compositions containing beta-diketones for promoting the enteric absorption of pharmacologically active substances
Pharmaceutical compositions containing beta-diketones for promoting the enteric absorption of pharmacologically active substances
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机译:含有β-二酮的药物组合物,用于促进药理活性物质的肠吸收
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摘要
Pharmaceutical compositions for oral or rectal administration comprise (1) a ???-diketone compound having the following formula (I IMAGE wherein R is an alkyl group substituted by one or more substituent groups selected from hydroxy, sulfo, carboxy, phospho, ammonium and amino, or a derivative of the substituent group (e.g. esters, amides, salts); or is an aralkyl, aryl or heterocyclic group, which groups may optionally be substituted by one or more of the aforesaid substituent groups; or is an alkyl-substituted heterocyclyl-alkylene group; Y is an oxygen atom, a sulphur atom or an imino group; and R is an alkyl group; and (2) a pharmacologically active substance (e.g. insulin, ???-lactam antibiotics). The ???-diketones (I) are for promoting the absorption of the pharmacologically active substance through the enteric tract.
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