NEW ANTIBIOTIC ISTAMYCIN A1, B1, C1 OR A2

摘要

NEW MATERIAL:An antibiotic substance istamycin A1, B1, C1 or A2 expressed by formulaI(R1 is amino and R2 is H; or R1 is H and R2 is amino: R3 is HCO- or NH2CO-, R4 is methyl or ethyl) or an acid addition salt thereof. EXAMPLE:Istamycin A1 expressed by formula II. USE:An antimicrobial agent capable of inhibiting the growth of Gram-positive and Gram-negative bacteria with low toxicity. PROCESS:A microorganism, e.g. Streptomyces tenjimariensis SS-939 strain (FER M-P No.4932), capable of producing istamycin is inoculated into a culture medium containing nutrient sources utilizable by ordinary microorganisms, and cultivated aerobically by the spinner culture method in the liquid usually at 25-30 deg.C for 2-7 days. The aimed substance in the culture fluid is then adsorbed by various adsorbents, eluted, purified and separated by the thin layer chromatography, etc. to give the aimed istamycin A1, B1, C1 or A2.