Method for preparing acid compounds (6 - 7 - 1,2 dihydro - phenyl - 2 - 3 - oxopiridina carbonylamino) - fenilacetamino - 3 - methyl - 3-cephem-4-carboxylic - carboxylic acid and its Salts

摘要

Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) IMAGE (I) IMAGE wherein R1 and R2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R3 represents hydrogen or a lower alkyl group; R4 represents hydrogen or a hydroxyl group; and R5 represents IMAGE +TR IMAGE wherein R6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a -(CH2)n-SO3Na group, or a -(CH2)n-COR9 group [wherein R9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an IMAGE group, (wherein R10 and R11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.