首页>
外国专利>
method for production of alpha globulin for intravenous injection and the therapeutic agent is obtained
method for production of alpha globulin for intravenous injection and the therapeutic agent is obtained
展开▼
机译:静脉注射用α球蛋白的制备方法及治疗剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method of producing gamma -globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating gamma -globulin with pepsin or uropepsin in a neutral pH range of 6.0 to 7.5. The aggregates in gamma -globulin are selectively decomposed by the method of the present invention, while any decomposition of monomer gamma -globulin molecule is substantially prevented. A therapeutic agent for intravenous injection which is reduced its anticomplementary activity and is stabilized by adding uropepsin which serves simultaneously as a proteolytic enzyme and a stabilizer, to human gamma -globulin. Uropepsinogen can be also as a stabilizer.
展开▼