METHOD OF MAKING THE PENTAHYDRATE OF +L6R,7R+P-7-+L+LZ+P-2-+L2-AMINOTHIAZOL-4-YL+P-2-+L2-CARBOXYPROP-2-OXYIMINO+P ACETAMIDO+P-3-+L1-PIRIDINIUMMETHYL+PCEF-3-EM-4-CARBOXYLATE

摘要

(6R,7R)-7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(2-carboxyprop-2-oxyimino)ace tamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate in the form of its crystalline pentahydrate. This pentahydrate has a well defined crystalline structure and exhibits good stability on storage. The pentahydrate exhibits excellent antibiotic activity, particularly against organisms which are normally difficult to combat with beta -lactam antibiotics.