PROCESS FOR PREPARING 7BETA-/HALO-ARYL /-MALONAMIDO/- 7ALPHA-METHOXY-3-/ ALKYL-TETRAZOL-5-YL- OR -1,3,4-THIADIAZOL-2-YL /-THIOMETHYL/- 1-DETHIA-1-OXA-3-CEPHEM-4-CARBOXYLIC ACID DERIVATIVES

摘要

Antibacterial haloarylmalonamido-1-dethia-1-oxacephalosporins of the following formula: IMAGE wherein Ar is IMAGE IMAGE +TR IMAGE (in which Hal and Hal' each is halogen and RO is hydroxy or protected hydroxy); COA and COB each is carboxy or protected carboxy including a pharmaceutically acceptable salt group; and Het is 1-lower alkyl-5-tetrazolyl, 1,3,4-thiadiazol-2-yl or 5-lower alkyl-1,3,4-thiadiazol-2-yl, a pharmaceutical or veterinary composition comprising the said haloarylmalonamido-1-dethia-1-oxacephalosporin and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering an effective amount of the said antibacterial compound.