Solvate of amoxicillin, process for the preparation of this and process for the preparation of injection preparations FROM THIS solvate.

摘要

The invention provides as a new substance the solvate of sodium amoxicillin with N-methyl-2-pyrrolidone, which is a stable product from which injectable solutions can conveniently be produced. …??The invention also includes the preparation of the solvate by reacting amoxicillin with a solution of a source of sodium ions and subsequently causing the solvate to precipitate by addition of one or more organic solvents in the presence of N-methyl-2-pyrrolidone. …??The invention further includes the preparation of injectable solutions from the solvate by generally known methods.