Procedure for the preparation of the acid 7- (4-hydroxy-0 (-N-methylenamino-phenylacetamido) -3- (1,2,3-triazol-5-il-tio-methyl) -3-cefem-4-carboxylic . (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the obtaining of acid 7- (4-hydroxy-o (-N-methylenamino-phenylacetamido) -3 (1,2,3-triazol-5-il-tio-methyl) -3-cefem-4-carboxylic, of formula (I), in which r is the group -n = ch, and of its salts with alkaline metals, compounds that have pharmacological applications for the preparation of injectables or syrup, as antibacterials, consists in the reaction of an aqueous dissolution of formula cefatrizine (I), in which r -nh with aqueous formaldehyde, the reaction is carried out at a ph interval comprised between 7.5 and 8 at the ambient temperature. The product obtained is separated and purified by crystallization in isopropanol ice. (Machine-translation by Google Translate, not legally binding)