wherein either (a) R1 is hydroxy and R2 is hydrogen, or (b) R1 is methoxy and R2 is hydroxy, or a salt thereof, are produced by the cultivation of the organism Streptomyces hygroscopicus TM-531 under aerobic conditions. They are separated from coproduced Antibiotic TM-531 as disclosed in U.S. Patent No. 4,269,971 and from each other by chromatography on silica gel."/>
公开/公告号EP0048585A1
专利类型
公开/公告日1982-03-31
原文格式PDF
申请/专利权人 TAISHO PHARMACEUTICAL CO. LTD;
申请/专利号EP19810304209
发明设计人 OTAKE NOBORU;OMURA SADAFUMI;SETO HARUO;YAMAGISHI MICHIO;KAWASHIMA AKIRA;MIZUTANI TAKU;MIZOUE KAZUTOSHI;
申请日1981-09-15
分类号C07D493/10;A61K31/335;C12P17/18;C12P19/44;
国家 EP
入库时间 2022-08-22 13:07:40