wherein either (a) R1 is hydroxy and R2 is hydrogen, or (b) R1 is methoxy and R2 is hydroxy, or a salt thereof, are produced by the cultivation of the organism Streptomyces hygroscopicus TM-531 under aerobic conditions. They are separated from coproduced Antibiotic TM-531 as disclosed in U.S. Patent No. 4,269,971 and from each other by chromatography on silica gel."/> Antibiotics TM-531 B and TM-531 C
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Antibiotics TM-531 B and TM-531 C

机译:抗生素TM-531 B和TM-531 C

摘要

The novel antibiotics represented by the formulawherein either (a) R1 is hydroxy and R2 is hydrogen, or (b) R1 is methoxy and R2 is hydroxy, or a salt thereof, are produced by the cultivation of the organism Streptomyces hygroscopicus TM-531 under aerobic conditions. They are separated from coproduced Antibiotic TM-531 as disclosed in U.S. Patent No. 4,269,971 and from each other by chromatography on silica gel.
机译:该配方代表的新型抗生素 <图像文件=“ IMGA0001.GIF” he =“ 50” id =“ ia01” imgContent =“ chem” imgFormat =“ GIF” inline =“ no” wi =“ 110” /> < /化学>其中(a)R 1 是羟基,R 2 是氢,或(b)R 1 是甲氧基,R < Sup> 2 是羟基或其盐,是通过在有氧条件下培养Streptomyces hygroscopicus TM-531生物产生的。如美国专利No.4,269,971中所公开,它们与共同生产的Antibiotic TM-531分离,并通过硅胶色谱法彼此分离。

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