Cyclo- (Nuarr; epsi; uarr; -allidin), Nuarr; alpha; uarr; -Arginyl-cyclo - (Nuarr; epsi; uarr; -1-lysine, 6-glycine) bradykinin and Cyclo - (omega; -aminododecanoyl) bradykinin and their use

摘要

Novel cyclic analogues of callidine have the following general formula: IMAGE wherein Pro is moiety of L-proline, Gly-that of glycine, Phe-phenylalanine, Arg-L-argenine; R is a residue of alpha - or omega -aminoacid or peptide; R1 is a residue of alpha - or omega - amino-acid; R2 is L-serine or glycine, the carbonyl group of arginine being connected either with R or with R1 by means of a covalent peptide bond using the omega -amino group of the aminoacid located in the 1 or 2 position of the calladine sequence. The novel compounds according to the present invention possess a prolonged hypotensive effect of selective character.