DIMETHYL SULFOXIDE ADDUCTS OF SODIUM 6-(D(-)-ALPHA-(4-HYDROXY-1,5-NAPHTHYRIDINE-3-CARBOXAMIDO)PHENYLACETAMIDO)PENICILLANATE OR THE DERIVATIVE THEREOF BEARING A HYDROXYL GROUP AT THE P-POSITION OF THE PHENYL GROUP, METHODS FOR THEIR PREPARATION AND DECOMPOSITION, AND THEIR USE AS INTERMEDIATES FOR PURIFYING THE CRUDE PENICILLINS

摘要

Sodium 6- D (-)[- alpha -(4-hydroxy-1,5-naphtthydridine-3-carboxyamido) phenylacetamido] penicillanate or the derivative thereof bearing alydroxylgroup at the p-position of the phenyl group in a crude state can be purified efficiently through the reaction with dimethyl-sulfoxide in a liquid medium and decomposition of the obtained adducts in a water-containing liquid medium.