Pharmaceutical package for the treatment of symptoms of the menopause in women.

摘要

A method for treating menopausal symptoms and a pharmaceutical package for effecting the method are disclosed. The method comprises a three phase sequence of estrogen and progestogen administration and an additional drug-free fourth phase during at least one menstrual cycle as follows:PP(a) as phase one, 0.2 mg to 1.5 mg of estrone, (or of other natural estrogen in an amount sufficient to result in an effect equivalent to the selected amount of estrone within the aforegiven range) for 4-9 days, followed byPP(b) as phase two, 0.2 mg to 1.5 mg of estrone, (or of other natural estrogen in an amount sufficient to result in an effect equivalent to the selected amount of estrone within the aforegiven range), plus 0.2 to 1.5 mg of norethisterone (or of other styptic progestogen, in an amount sufficient to result in an effect equivalent to the selected amount of norethisterone within the aforegiven range); with the proviso that the dosage levels of estrogen and progestogen be approximately equal (as defined in terms of estrone and nonethisterone above); for 6-11 days, followed byPP(c) as phase three, twice the dosage of estrogen and twice the dosage of progestogen used in phase two, for at least 6 days, or for an arbitrarily selected greater number of days to a maximum of 90 days; followed byPP(d) as phase four, no therapeutically active dosage, i.e., either no treatment or a placebo, for 6-8 days.