Pharmaceutical veterinary compsns. contg. pyrethrinoid(s) - for treatment of mange and ticks by oral, parenteral or topical application

摘要

Novel compsns. contain =1 cis or trans, racemic or optically active pyrethrinoid of formula (I): In (I) Rl = H, halogen, or 1-8C alkyl; R2 = H, halogen, 1-8C alkyl or 2-8C alkoxycarbonyl; or Rl and R2 together form a 3-6C cycloalkyl group; and R = a radical of formula: or a mixture of these, such that when Rl and R2 are both Cl or are both CH3, then R is neither of the last two formulae given above. Used for treatment of various forms of mange (sarcoptic, psoroptic and chorioptic), and to combat ticks. A typical prod. is 5-benzyl-3-furyl methyl d-transchrysanthemate. In an example, an injectable soln. was prepd. contg. 2 g. of this ester, 6.65 g. piperonyl butoxide, 0.33 g. alpha-tocopherol acetate, 29 g. benzyl benzoate, and peanut oil to 100 ml.