New oxime o - substituted by a radical comprising a quaternary ammonium and derived of the acid 7 - amino cephalosporanic, their process of preparation and their application as medicinal products

摘要

Novel oximes of the syn isomers of 7-(2-amino-4-thiazolyl)-acetamido-cephalosporanic acid of the formula IMAGE I wherein R is selected from the group consisting of hydrogen, chlorine, methoxy, alkyl and alkylthio of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, acetoxymethyl, carbamoyloxymethyl, IMAGE A1K is 1 to 4 carbon atoms, azidomethyl and -CH2-S-R' and R' is selected from the group consisting of a nitrogen heterocycle optionally substituted, acyl of an alkanoic acid of 2 to 4 carbon atoms, 2-oxo-(3H)-thiazolin-4-yl-carbonyl and 3-methyl-1,2-oxazol-5-ylcarbonyl, n is an integer from 2 to 4, R1, R2 and R3 are individually alkyl of 1 to 4 carbon atoms or together taken with the nitrogen atom they are attached to form a group selected from the group consisting of 1,4-diazobicyclo (2,2,2)octan-1-ylium and 1,3,5,7-tetraazatricyclo(3,3,1,13,7) decan-1-ylium and their non-toxic, pharmaceutically acceptable acid addition salts having antibacterial properties and process for their preparation and novel intermediates.