PROCESS FOR THE PREPARATION OF PROSTAGLANDIN F2A AND THEIR APPROVALS

摘要

P THE PRESENT INVENTION CONCERNS A PROCESS FOR THE PREPARATION OF PROSTAGLANDIN FA BY REACTION OF A LACTONEDIOL WITH A 1-ALCOXYBENZYL HALIDE IN A SOLUTION OF AROMATIC HYDROCARBON IN THE PRESENCE OF TERTIARY AMINE AT A TEMPERATURE OF -20 TO -40C. , CHARACTERIZED IN THAT THE LACTONE OBTAINED IS TRANSFORMED INTO THE CORRESPONDING LACTOL BY REDUCTION, WHICH WE REACT WITH A "YLURE" TO GIVE A BISACETAL OF PROSTAGLANDIN FROM WHICH THE PROSTAGLANDIN IS RELEASED. /P