Synthesis of intermediates for tetramisole, levamisole and their derivatives

摘要

A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4- imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2- alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, di-2,3, 5,6-tetrahydro-6-phenylimidazo- 2,1-b!thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.