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Renal dilating methods and compositions using 4-(3,4- dihydroxyphenyl)-1, 2, 3,4-tetrahydroisoquinolines
Renal dilating methods and compositions using 4-(3,4- dihydroxyphenyl)-1, 2, 3,4-tetrahydroisoquinolines
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机译:使用4-(3,4-二羟基苯基)-1,2,3,4-四氢异喹啉的肾扩张方法和组合物
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摘要
4-Phenyl-1,2,3,4-tetrahydroisoquinolines whose structures have two hydroxy groups substituted at the 3,4-position on the 4-phenyl ring have been found to have renal vasodilating activity upon internal administration. The active ingredients are prepared by cyclizing N-(2- substituted benzyl)-1-(3,4-dimethoxyphenyl)-aminoethanol using either a Lewis acid or an acid cyclizing agent followed by demethylation at the 3, 4- dimethoxyphenyl moiety.
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