REMEDY FOR SENILE PRURITUS, SENILE KERATOSIS AND PROGRESSIVE PALMAR KERATODERMA

摘要

PURPOSE:To provide a remedy for senile pruritus, senile keratosis and progressive palmar keratoderma, having high safety and exhibiting its effect in a short time, by using L-carnosine or its salt which is an oligopeptide existing in the living body, as an active component. CONSTITUTION:The objective remedy for senile pruritus, senile keratosis and progressive palmar keratoderma contains L-carnosine or its salt as an active component. L-Carnosine can be prepared by chlorinating carbobenzoxy-beta-alanine with phosphorus pentachloride, reacting with methanol to obtain methyl ester, converting the product to azide via hydrazide, coupling with L-histidine methyl ester, and finally eliminating the carbobenzoxy group by catalytic reduction. L- Carnosine can be administered by scattering to the affected part in the form of powder, by applying to the affected part in the form of ointment, or by intravenous injection, etc.