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INDOMETHACINE GRADULALLY RELEASING TABLET

机译:消炎痛缓释片

摘要

PURPOSE:The titled gradually releasing tablets that are prepared by coating particles of indomethacine, as an active ingredient, with a hydrophilic high- molecular film-formig substance and ethyl cellulose at a specific ratio respectively, thus showing tabletting properties (stable with time) with gradual release behavior imparted. CONSTITUTION:The objective indomethacine gradually releasing tablets are prepared by using a mixture of powdery indomethacine as an active ingredient, (a) a hydrophilic high-molecular film-forming substance as a stabilizer, preferably selected from hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxypropylmethylcellulose phthalate and polyvinyl pyrrolidone, much preferably hydroxypropylmethylcellulose phthalate and (b) ethyl cellulose as a gradually releasing agent in proportions of 1-50, preferably 3-20wt% respectively. The weight ratio of (a) to (b) is preferably 1:9-5:5.
机译:目的:通过分别以特定比例用亲水性高分子成膜物质和乙基纤维素包衣作为活性成分的吲哚美辛颗粒制备的标题缓释片剂,从而显示出片剂的性质(随时间变化是稳定的)。逐渐释放行为。组成:以吲哚美辛粉为有效成分的混合物,可制备客观的吲哚美辛缓释片,(a)以亲水性高分子成膜物质为稳定剂,优选选自羟丙基纤维素,羟丙基甲基纤维素,羟丙基甲基纤维素邻苯二甲酸酯和聚乙烯吡咯烷酮,更优选羟丙基甲基纤维素邻苯二甲酸酯和(b)乙基纤维素作为逐渐释放剂,其比例分别为1-50wt%,优选3-20wt%。 (a)与(b)的重量比优选为1:9-5:5。

著录项

  • 公开/公告号JPS58170712A

    专利类型

  • 公开/公告日1983-10-07

    原文格式PDF

  • 申请/专利权人 CHIYODA YAKUHIN KK;

    申请/专利号JP19820054314

  • 申请日1982-03-31

  • 分类号A61K31/405;A61K9/22;A61K31/455;A61K47/38;A61P9/08;A61P9/10;

  • 国家 JP

  • 入库时间 2022-08-22 11:40:32

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