MICROCAPSULE FOR INTRACRANIAL ANTI HYPOTENSION AND ITS PRODUCTION

摘要

PURPOSE:A specific propanol derivative is made into microcapsules utilizing the phase separation of an organic solvent solution containing ethylcellulose, thus producing the titled micocapsules used as a remedy for intracranial hypertension such as intracerebral hemorrhage. CONSTITUTION:A compound of the formula (R is lower alkyl; ring A is phenyl, halogenophyenyl, methylphenyl, trifluoromethylphenyl) or its acid adduct is coated with ethylcellulose into microcapsules for intracranial antihypotension. The coating is effected by dissolving ethylcellulose in an organic solvent with heat, dispersing the compound of the formula or its salt in it, then cooling them to cause the phase separation on the active ingredient. The resultant preparation is readily dosed orally with no side-effects, becaue of its form, and sustains its activity for hours. The dose of the compound is 30-150mg/day.