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Process for the preparation of 3-amino (1) benzazepin-2-one-1-alkanoic acids or stereoisomers, salts or complexes thereof
Process for the preparation of 3-amino (1) benzazepin-2-one-1-alkanoic acids or stereoisomers, salts or complexes thereof
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机译:制备3-氨基(1)苯并ze庚因-2-一-1-链烷酸或其立体异构体,盐或络合物的方法
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摘要
The invention concerns angiotensin- converting enzyme (ACE) inhibitors of the formula I IMAGE wherein RA and RB are radicals of the formula IMAGE respectively, in which Ro is carboxy or a functionally modified carboxy; R1 is hydrogen, lower alkyl, amino(lower) alkyl, aryl, aryl (lower) alkyl, cycloalkyl or cycloalkyl (lower) alkyl; R2 is hydrogen or lower alkyl; R3 and R4, each independently, represent hydrogen, lower alkyl, lower alkoxy, lower alkanoyloxy, hydroxy, halogen, trifluoromethyl, or R3 and R4 taken together represent lower alkylenedioxy; R5 is hydrogen or lower alkyl, and X represents oxo, two hydrogens, or one hydroxy together with one hydrogen; and wherein the carbocyclic ring may also be hexahydro or 6,7,8,9- tetrahydro; salts and complexes thereof; and stereoisomers of all these compounds. They are prepared, for example, by reducing a compound corresponding to the formula I, having an additional double bond located at the carbon atom in 3-position.
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机译:本发明涉及式I 的血管紧张素转化酶(ACE)抑制剂,其中RA和RB分别为式的基团,其中Ro为羧基或官能改性的羧基; R1是氢,低级烷基,氨基(低级)烷基,芳基,芳基(低级)烷基,环烷基或环烷基(低级)烷基; R 2是氢或低级烷基; R 3和R 4各自独立地表示氢,低级烷基,低级烷氧基,低级烷酰氧基,羟基,卤素,三氟甲基,或R 3和R 4一起表示低级亚烷基二氧基; R5是氢或低级烷基,X表示氧代,两个氢或一个羟基与一个氢一起;其中碳环也可以是六氢或6,7,8,9-四氢;盐及其络合物;和所有这些化合物的立体异构体。它们例如通过还原对应于式I的化合物而制备,所述化合物具有在3-位的碳原子处的另外的双键。
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