process for the preparation of asymmetric dicarbonzuuresters,and for the preparation of a reagent for the study of cardiac glycosides (digitalis glycosides) in an aqueous or physiological solution.

摘要

New reactive asymmetrical dicarboxylic acid ester compounds of the formula IMAGE (I) wherein R1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R2 and R3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5, are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).