PROCESS FOR PREPARING A THERAPEUTIC PREPARATION CONTAINING A 6-PHENYL-4H-S-TRIAZOLO Ÿ4,3-AŸŸ1,4Ÿ BENZODIAZEPINE.

摘要

6-Phenyl-4H-s-triazolo 4,3-a 1,4 -benzodiazepines. Title compds. opt. substd. in the 1-position by 1-3 C alkyl, phenyl, benzyl or -COO(1-4C-alkyl), in the 4-position by 1-3C alkyl and in the 6-phenyl residue and in the benzene ring of the heterocyclic ring system by 1-3C alkyl, halogen, NO2,CN,CF3, O-Alkyl, S-Alkyl, SO Alkyl, So2Alkyl, NHCO Alkyl or N(Alkyl)2 (Alkyl = 1-3C) and their salts are tranquilisers (but the fluosilicate salt is an antimite agent and the trichloroacetate salt is a herbicide) are prepd. by reacting a 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione with a acylhydrazine and cyclising the 2-(2-acylhydrazino)5-phenyl-3H-1,4-benzodiazepine (also claimed) so formed.