A process for the preparation of Polyether type mocrociclicos exemplified by 1,4,7,10,13,16 - hexaoxaciclooctadecano.

摘要

A process for the preparation of macrocyclic polyethers type exemplified by 1, 4, 7, 10, 13, 16 hexaoxaciclooctadecano. A sulfonyl Halide is reacted in the presence of a base with a glycol in the presence of a Solvent containing Halogen Halide; this is a alcohil - sulfonyl chloride with up to six carbon Atoms per moleculo.The Solvent employed is a Halogenated aliphatic Hydrocarbon Pole, a Halogenated aromatic hydrocarbon, dichloromethane or chlorobenzene. The Solvent containing Halogen is present in a Weight ratio of solvent, reactants in the range 2 10. To