Levonantradol and N-methyllevonantradol formulations.

摘要

PROCEDURE FOR THE PREPARATION OF STABLE AQUEOUS MICELLAR SOLUTIONS OF LEVONANTRADOL AND N-METHYL-LEVONANTRADOL. UNDERSTANDS THE FOLLOWING OPERATIONS: FIRST, LEVONANTRADOL OR N-METHYL-LEVONANTRADOL, OR AN ADDITIONAL SALT OF ACID, PHARMACEUTICALLY ACCEPTABLE, IS SOLVED AT A SOLUTION BY AN ANIFIFILIC CONCENTRATE WITH NO ION AND IN A VOLUME LESS THAN THE TOTAL VOLUME OF WATER THAT HAS TO BE PRESENT IN THE FINAL FORMULATION; SECOND, THE FORMED SOLUTION IS SUBMITTED TO AGITATION; THIRD, ANTIOXIDANTS, EXCIPIENTS AND BUFFERS ARE ADDED; AND LASTLY, THE PH IS ADJUSTED AND THE ADDITIONAL WATER NECESSARY IS ADDED TO ACHIEVE THE DESIRED CONCENTRATION OF ACTIVE INGREDIENT IN THE FINAL FORMULATION. OF APPLICATION IN PHARMACEUTICAL PREPARATIONS FOR PARENTERAL USE. (Machine-translation by Google Translate, not legally binding)