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A process for the preparation of stable Aqueous Solutions of mineral levonantradol and n-methyl levonantradol.
A process for the preparation of stable Aqueous Solutions of mineral levonantradol and n-methyl levonantradol.
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机译:一种制备矿物乙酰丙酮和正甲基乙酰丙酮的稳定水溶液的方法。
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摘要
Process for the preparation of stable aqueous Micellar Solutions of levonantradol and n-methyl levonantradol.It includes the following Operations: First, the levonantradol dissolves at room temperature or n-methyl levonantradol, addition of acid or a Salt thereof, a pharmaceutically acceptable, in a solution of a nonionic amphiphile with a critical Micelle concentration and Volume in a Less than the total volume of water must be present in the final formulation; Second,The solution formed is subjected to agitation; Third, Add the Antioxidant, Excipients and buffers; and lastly, it adjusts the pH and add additional Water is necessary to achieve the desired concentration of active ingredient in the final formulation. Application in Pharmaceutical preparations for parenteral use.
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