VACCINE FOR ACTIVE IMMUNIZATION CONTAINING HEPATITIS B SURFACE AND/OR E -ANTIGENS

摘要

An antigenic composition, useful as a vaccine or vaccine intermediate, comprising a subparticulate mass containing hepatitis B surface and hepatitis B e antigens which have a particle size less than 20 nm, especially less than 5 nm, is obtained by contacting an antigenic mass containing particles of HBsAg of a particle size of at least 20 nm with a detergent followed by treating the detergent-containing antigenic composition with an aqueous aldehyde solution.