Novel bis- and mono-quaternary ammonium derivatives of 2-beta, 16-beta-dipiperidino-5-alpha-androstanes, processes for their preparation and pharmaceutical preparations

摘要

The invention relates to novel bisquaternary ammonium derivatives of 2 beta ,16 beta -dipiperidino-5 alpha -androstanes having the formula: IMAGE wherein IMAGE R2=CH3, C2H5 or CH2CH=CH2; R3=CH3, C2H5 or CH2CH=CH2, with the proviso that R2 and R3 are not CH3 simultaneously; R4=O or H( beta OR5), wherein R5=H or aliphatic carbacyl (1-6 C); and X=a halogen atom, to processes for their preparation and to pharmaceutical preparations. The invention also relates to novel 16-monoquaternary analogs as intermediates. The compounds possess neuromuscular blocking activity.