2(2-acetamido-2-deoxy-3-O-D-glucopyranosyl)-alkanyl-pe-ptide I (R=methyl; R1=OH; R2=H, functional groups, C22-acyl; R4=OH; R6=OH, oxisuccinyl; R7=C1 C10 alkyl; X=L-alanyl, L-se-ryl, L-glycyl) was prepd. as immune adjuvant. Thus, t-butyl-oxycarbonyl-D-gln-methyl ester was dessolved in 60mL methanol and added to and ether soln. of CH2N2 at 0C Excess diazomethane was removed by addition of glacial acetic acid, and resulting mixture was concentrated and dried. As a resuly, Nacetyl-muramyl-L-Ala-D-Gin. methyl ester was obtained.
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机译:2(2-乙酰氨基-2-脱氧-3-OD-吡喃葡萄糖基)-烷基-肽I(R =甲基; R1 = OH; R2 = H,官能团,C22-酰基; R4 = OH; R6 = OH制备:氧杂环丁烷基; R 7 = C 1 C 10烷基; X = L-丙氨酰基,L-se-ryl,L-甘氨酰基)。作为免疫佐剂。因此,将叔丁基氧羰基-D-gln-甲基酯溶解在60mL甲醇中,并加入到乙醚溶液中。在0℃下除去CH 2 N 2,通过加入冰乙酸除去过量的重氮甲烷,并将所得混合物浓缩并干燥。因此,推荐使用Nacetyl-muramyl-L-Ala-D-Gin。获得了甲酯。
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